Chloe (Drew Barrymore), a diamond-clad, bootie wearing Beverly Hills Chihuahua enjoys her luxurious lifestyle so much, she hardly notices Papi (George Lopez), a tough looking Chihuahua who happens to be head-over-paws for the pampered pooch. But when Chloe gets lost in the rough streets of Mexico with only a street-wise German Shepherd to help her find her way home, Papi heads south of the border–joining forces with a motley crew: two humans, a sly rat and a nervous iguana–to rescue his true love.

Starring: Drew Barrymore, Piper Perabo, Jamie Lee Curtis, Edward James Olmos, Loretta Devine, George Lopez, and Cheech Marin.